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6 thg 2, 2024 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. …
1 thg 2, 2025 · To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time. It showed that ApoE3Ch clings onto tau …
18 thg 2, 2025 · Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s …
25 thg 11, 2024 · Background LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau. No information is available about …
7 thg 2, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau …
In both wild-type C57BL/6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies …
30 thg 1, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. …
22 thg 5, 2020 · Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. In a preprint on bioRxiv, …
23 thg 2, 2025 · In an autopsy-confirmed cohort, they found that plasma p-Tau217 flagged the presence of amyloid and tau pathology with high accuracy in people with frontotemporal …
This antibody's activity against pathologic tau seeds has been characterized in a cell-based seeding aggregation assay, in tau transgenic mice injected with Alzheimer's disease brain …
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